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Our Response to COVID-19

In our most recent research we are investigating the mutation landscape of COVID-19. As of March 2020 COVID-19 has mutated and expanded across the human species; a total of 214 haplotypes (i.e. sequence variations) and 344 different strains have been identified. Most of these variations, gained through mutation, recombination, and natural selection, have been found in the Spike (S) protein. We are developing a computational pipeline that estimates the mutation landscape of the COVID19’s S protein, and simultaneously  are measuring binding of the S protein to the human receptor ACE2 using cryo-electron microscopy.