4-catenane-COLLAGE

Applications of topology to study DNA and chromosomes

Our group is interested in applications of knot theory and low-dimensional topology to understand the three dimensional organization of the genome in different organisms. We are also interested in the applications of computational homology to analyze genomic data.

Our current main interests are:

DNA Packing in Bacteriophages

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Minicircle Organization in kDNA Networks of Trypanosomes

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The Geometry and Topology of Chromatin During Interphase

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DNA unlinking

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The Tangle Method for Site-specific Recombination

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Applications of Computational Homology to the Analysis of Copy Number Changes in Breast Cancer